Aging and chronic inflammation: highlights from a multidisciplinary workshop

Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system characterized by a decrease in thymic output of naïve lymphocytes, an accumulated chronic a...

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Published in:Immunity & ageing Vol. 20; no. 1; pp. 25 - 10
Main Authors: Saavedra, Danay, Añé-Kourí, Ana Laura, Barzilai, Nir, Caruso, Calogero, Cho, Kyung-Hyun, Fontana, Luigi, Franceschi, Claudio, Frasca, Daniela, Ledón, Nuris, Niedernhofer, Laura J., Pereira, Karla, Robbins, Paul D., Silva, Alexa, Suarez, Gisela M., Berghe, Wim Vanden, von Zglinicki, Thomas, Pawelec, Graham, Lage, Agustín
Format: Journal Article
Language:English
Published: London BioMed Central 08.06.2023
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Age
Aging
Antibodies
Antidiabetics
Antigens
B cells
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cell cycle
Cell senescence
Chronic inflammation
Clinical Nutrition
Conferences, meetings and seminars
Cytomegalovirus
Epigenetics
Geriatrics/Gerontology
Health aspects
Immune response
Immune system
Immunology
Immunosenescence
Inflammaging
Inflammation
Lymphocytes
Memory
Older people
Pathogens
Phenotypes
Physiological aspects
Public Health
Review
SASP
Senescence
Thymus
Cuba
Cell senescence
Chronic inflammation
Senolytic
Aging
Immunosenescence
Inflammaging
Metformin
Biomodulina T
SASP
ISSN:1742-4933, 1742-4933
Online Access:Get full text
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Summary:Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system characterized by a decrease in thymic output of naïve lymphocytes, an accumulated chronic antigenic stress notably caused by chronic infections such as cytomegalovirus (CMV), and immune cell senescence with acquisition of an inflammatory senescence-associated secretory phenotype (SASP). For this reason, and due to the SASP originating from other tissues, aging is commonly accompanied by low-grade chronic inflammation, termed “inflammaging”. After decades of accumulating evidence regarding age-related processes and chronic inflammation, the domain now appears mature enough to allow an integrative reinterpretation of old data. Here, we provide an overview of the topics discussed in a recent workshop “Aging and Chronic Inflammation” to which many of the major players in the field contributed. We highlight advances in systematic measurement and interpretation of biological markers of aging, as well as their implications for human health and longevity and the interventions that can be envisaged to maintain or improve immune function in older people.
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ISSN:1742-4933
1742-4933
DOI:10.1186/s12979-023-00352-w