Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry

Glycosylated α-dystroglycan (α-DG) serves as cellular entry receptor for multiple pathogens, and defects in its glycosylation cause hereditary Walker-Warburg syndrome (WWS). At least eight proteins are critical to glycosylate α-DG, but many genes mutated in WWS remain unknown. To identify modifiers...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 340; no. 6131; p. 479
Main Authors:	Jae, Lucas T, Raaben, Matthijs, Riemersma, Moniek, van Beusekom, Ellen, Blomen, Vincent A, Velds, Arno, Kerkhoven, Ron M, Carette, Jan E, Topaloglu, Haluk, Meinecke, Peter, Wessels, Marja W, Lefeber, Dirk J, Whelan, Sean P, van Bokhoven, Hans, Brummelkamp, Thijn R
Format:	Journal Article
Language:	English
Published:	United States 26.04.2013
Subjects:	Amino Acid Sequence Cell Line Dystroglycans - metabolism Female Glycosylation Haploidy Host-Pathogen Interactions - genetics Humans Infant Lassa Fever - genetics Lassa Fever - virology Lassa virus - physiology Male Membrane Proteins - genetics Molecular Sequence Data Mutation Pedigree Proteome - metabolism Virus Internalization Walker-Warburg Syndrome - genetics
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!