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[...]the presence of substantial uncertainty in the results suggests the possibility of a minimally clinically important difference, which may have been influenced by patient selection. [...]it cannot be excluded that a subset of patients may indeed benefit from hypothermia treatment. [...]there is...

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Published in:Critical care (London, England) Vol. 27; no. 1; pp. 280 - 2
Main Author: Taccone, Fabio Silvio
Format: Journal Article
Language:English
Published: London BioMed Central 11.07.2023
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Cardiac arrest
Care and treatment
Complications and side effects
Correspondence
Critical care
Critical Care Medicine
Diagnosis
Emergency Medicine
Hypothermia
Intensive
Intensive care
Intervention
Medicine
Medicine & Public Health
Meta-analysis
Methods
Neurologic manifestations of general diseases
Patients
Systematic review
Temperature
Belgium
ISSN:1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X
Online Access:Get full text
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Summary:[...]the presence of substantial uncertainty in the results suggests the possibility of a minimally clinically important difference, which may have been influenced by patient selection. [...]it cannot be excluded that a subset of patients may indeed benefit from hypothermia treatment. [...]there is a need for improved patient selection criteria to identify those individuals at high-risk of moderate brain injury, i.e., those who are not too mildly affected, as they may not require a specific neuroprotective strategy, and not too severely affected, as they may have poor prognosis regardless of any intervention. Fernando SM, Di Santo P, Sadeghirad B, Lascarrou JB, Rochwerg B, Mathew R, Sekhon MS, Munshi L, Fan E, Brodie D, Rowan KM, Hough CL, McLeod SL, Vaillancourt C, Cheskes S, Ferguson ND, Scales DC, Sandroni C, Nolan JP, Hibbert B. Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-2
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ISSN:1364-8535
1466-609X
1364-8535
1466-609X
1366-609X
DOI:10.1186/s13054-023-04564-w