Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors

Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options and poor clinical prognosis. Inhibitors of transcriptional CDKs are currently under thorough investigation for application in the treatment of multiple cancer types, including breast cancer....

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Bibliographic Details
Published in:	Breast cancer research : BCR Vol. 25; no. 1; pp. 51 - 20
Main Authors:	van der Noord, Vera E., van der Stel, Wanda, Louwerens, Gijs, Verhoeven, Danielle, Kuiken, Hendrik J., Lieftink, Cor, Grandits, Melanie, Ecker, Gerhard F., Beijersbergen, Roderick L., Bouwman, Peter, Le Dévédec, Sylvia E., van de Water, Bob
Format:	Journal Article
Language:	English
Published:	London BioMed Central 05.05.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	ABCG2 Analysis Antibodies Antineoplastic Agents - pharmacology Antitumor agents Apoptosis ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism Biomedical and Life Sciences Biomedicine Breast cancer Cancer Cancer Research Cancer therapies Care and treatment CDK12/13 Cell cycle Cell growth Cell Line, Tumor CRISPR Cyclin-dependent kinase Cyclin-dependent kinases Cyclin-Dependent Kinases - genetics Drug dosages Drug interaction Drug resistance Enzyme inhibitors Gene expression Genetic aspects Genetic transcription Genomes Growth factors Humans Kinases Medical prognosis Neoplasm Proteins Oncology Oncology, Experimental Polyadenylation Prognosis Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Proteins Pyrimidines - pharmacology Reagents RNA polymerase RNA sequencing Sequence analysis Surgical Oncology Synergism THZ531 Transcription Transcriptional cyclin-dependent kinases Transcriptomics Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple-negative breast cancer Tyrosine Netherlands THZ531 Drug resistance CDK12/13 Triple-negative breast cancer Transcriptional cyclin-dependent kinases ABCG2
ISSN:	1465-542X, 1465-5411, 1465-542X
Online Access:	Get full text
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