Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn

Background The noradrenergic neurons of locus coeruleus (LC) project to the spinal dorsal horn (SDH), and release norepinephrine (NE) to inhibit pain transmission. However, its effect on pathological pain and the cellular mechanism in the SDH remains unclear. This study aimed to explore the analgesi...

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Bibliographic Details
Published in:	Journal of neuroinflammation Vol. 19; no. 1; pp. 123 - 19
Main Authors:	Li, Juan, Wei, Yiyong, Zhou, Junli, Zou, Helin, Ma, Lulin, Liu, Chengxi, Xiao, Zhi, Liu, Xingfeng, Tan, Xinran, Yu, Tian, Cao, Song
Format:	Journal Article
Language:	English
Published:	London BioMed Central 27.05.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adrenergic Neurons - metabolism Analgesics Analysis Animals Antibodies Astrocyte Astrocytes Astrocytes - metabolism Biomedical and Life Sciences Biomedicine Brain Care and treatment Cytokines Cytokines - metabolism Dorsal horn Experiments Genomes IL-1β Immunofluorescence Immunology Inflammation Interleukin 10 Interleukin 4 Laboratory animals Locus coeruleus Locus Coeruleus - metabolism Medical examination Mice Microglia Microglia - metabolism Neuralgia Neuralgia - metabolism Neurobiology Neuroinflammatory Diseases Neurology Neurons Neurosciences Noradrenaline Noradrenergic Norepinephrine Norepinephrine - metabolism Norepinephrine/noradrenaline Pain Pain perception Somatosensory system Spinal cord Spinal Cord Dorsal Horn - metabolism Structure Tumor necrosis factor-α Viruses Yohimbine China United Kingdom > UK United States > US Japan Spinal cord Pain Noradrenergic Cytokine Astrocyte Norepinephrine/noradrenaline Locus coeruleus Microglia
ISSN:	1742-2094, 1742-2094
Online Access:	Get full text
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