Molecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases

Background Molecular targeted therapy increased overall and disease-free survival in a wide range of malignancies. Although generally well tolerated compared to chemotherapy, molecular targeted therapy may be associated with adverse events requiring ICU admission. Informing clinicians about clinical...

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Bibliographic Details
Published in:	Intensive care medicine Vol. 45; no. 7; pp. 988 - 997
Main Authors:	Assoun, Sandra, Lemiale, Virginie, Azoulay, Elie
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2019 Springer Springer Nature B.V
Subjects:	Adverse events Anesthesiology Angiogenesis Angiogenesis Modulating Agents - adverse effects Antiangiogenic agents Antiangiogenics Antimitotic agents Antineoplastic agents Biomarkers Cancer Cardiovascular Diseases - chemically induced Cardiovascular Diseases - therapy Care and treatment Case reports Chemotherapy Comparative analysis Complications and side effects Critical Care Medicine Drug approval Drug Hypersensitivity - therapy Emergency Medicine Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB-2 protein Evidence-based medicine Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - therapy Health services Humans Hypersensitivity Immune checkpoint inhibitors Immunologic Factors - adverse effects Inhibitors Intensive Intensive care Intensive Care Units Malignancy Medicine Medicine & Public Health Molecular Targeted Therapy - adverse effects Monoclonal antibodies Neoplasms - drug therapy Pain Medicine Patients Pediatrics Pneumology/Respiratory System Receptor, ErbB-2 - antagonists & inhibitors Respiratory Tract Diseases - chemically induced Respiratory Tract Diseases - therapy Review Schedules Severity of Illness Index Side effects Signs and symptoms Systematic review Targeted cancer therapy Toxicity Critical care Molecular targeted therapy Digestive perforation Pneumonitis Malignancies
ISSN:	0342-4642, 1432-1238, 1432-1238
Online Access:	Get full text
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