Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements

Background Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, we will evaluate if dietary SAA restriction can reduce body weight and improve re...

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Vydáno v:	Journal of translational medicine Ročník 19; číslo 1; s. 153 - 11
Hlavní autoři:	Stolt, Emma, Olsen, Thomas, Elshorbagy, Amany, Kožich, Viktor, van Greevenbroek, Marleen, Øvrebø, Bente, Thoresen, Magne, Refsum, Helga, Retterstøl, Kjetil, Vinknes, Kathrine J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 15.04.2021 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Adipose tissue Adolescent Adult Alcohol use Amino Acids Amino Acids, Sulfur Animal models Bioenergetics Biomedical and Life Sciences Biomedicine Body Composition Body mass index Body weight Calorimetry Clinical trials Cysteine Cysteine restriction Diet Diet therapy Dietary intervention Dietary restrictions Dietary supplements Dual energy X-ray absorptiometry Energy expenditure Energy Metabolism Female Food plants Gene expression Health aspects Humans Intervention Life span Male Medical research Medicine/Public Health Metabolism Methionine Methionine restriction Middle Aged Natural foods Nutrient deficiency Nutrition & metabolism Nutrition research Obesity Overweight Plasma biomarkers Protocol Randomized Controlled Trials as Topic Sulfur Sulfur amino acids Translational research Weight control Womens health Young Adult Norway Obesity Dietary intervention Translational research Adipose tissue Plasma biomarkers Metabolic health Cysteine restriction Gene expression Methionine restriction Sulfur amino acids
ISSN:	1479-5876, 1479-5876
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Shrnutí:	Background Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, we will evaluate if dietary SAA restriction can reduce body weight and improve resting energy expenditure (REE) and parameters related to metabolic health. Method/design Men and women (calculated sample size = 60), aged 18–45 years, with body mass index of 27–35 kg/m 2 will be included in a double-blind 8-week dietary intervention study. The participants will be randomized in a 1:1 manner to a diet with either low or high SAA. Both groups will receive an equal base diet consisting of low-SAA plant-based whole foods and an amino acid supplement free of SAA. Contrasting SAA contents will be achieved using capsules with or without methionine and cysteine (SAA high , total diet SAA ~ 50–60 mg/kg body weight/day; SAA low , total diet SAA ~ 15–25 mg/kg body weight/day). The primary outcome is body weight change. Data and material collection will also include body composition (dual X-ray absorptiometry), resting energy expenditure (whole-room indirect calorimetry) and samples of blood, urine, feces and adipose tissue at baseline, at 4 weeks and at study completion. Measures will be taken to promote and monitor diet adherence. Data will be analyzed using linear mixed model regression to account for the repeated measures design and within-subject correlation. Discussion The strength of this study is the randomized double-blind design. A limitation is the restrictive nature of the diet which may lead to poor compliance. If this study reveals a beneficial effect of the SAA low diet on body composition and metabolic health, it opens up for new strategies for prevention and treatment of overweight, obesity and its associated disorders. Trial registration ClinicalTrials.gov: NCT04701346, Registration date: January 8th, 2021
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1479-5876 1479-5876
DOI:	10.1186/s12967-021-02824-3