Mortality in Yusho patients exposed to polychlorinated biphenyls and polychlorinated dibenzofurans: a 50-year retrospective cohort study

Background In 1968, the Yusho incident resulted in accidental exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related compounds in Japan. This study updated the risk of mortality in Yusho patients. Methods We obtained updated cohort data for all Yusho patient...

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Published in:Environmental health Vol. 19; no. 1; p. 119
Main Authors: Onozuka, Daisuke, Nakamura, Yuko, Tsuji, Gaku, Furue, Masutaka
Format: Journal Article
Language:English
Published: London BioMed Central 23.11.2020
BioMed Central Ltd
Springer Nature B.V
Subjects:
Adult
Age
Aged
Aged, 80 and over
Carcinogens
Chemical Hazard Release - mortality
Cohort analysis
Confidence intervals
Dibenzofurans
Dibenzofurans, Polychlorinated - toxicity
Dietary Exposure - adverse effects
Disease
Earth and Environmental Science
Environment
Environmental Epidemiology
Environmental Health
Environmental Pollutants - toxicity
Exposure
Female
Females
Food Contamination
Food contamination & poisoning
Food poisoning
Health aspects
Humans
Japan - epidemiology
Liver cancer
Lung cancer
Male
Males
Middle Aged
Mortality
Mortality risk
Neoplasms - mortality
Occupational Medicine/Industrial Medicine
Patient outcomes
PCB
Polychlorinated biphenyls
Polychlorinated Biphenyls - toxicity
Polychlorinated dibenzofurans
Population
Porphyrias - chemically induced
Porphyrias - mortality
Public Health
Registration
Retrospective Studies
Young Adult
Japan
Polychlorinated biphenyls
Yusho
Cohort study
Polychlorinated dibenzofurans
Cancer
ISSN:1476-069X, 1476-069X
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Summary:Background In 1968, the Yusho incident resulted in accidental exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related compounds in Japan. This study updated the risk of mortality in Yusho patients. Methods We obtained updated cohort data for all Yusho patients for the period 1968–2017. We calculated standardized mortality ratios (SMRs) for all-cause and cause-specific mortality over a 50-year follow-up period compared with the general population in Japan. Results A total of 1664 Yusho patients with 63,566 person-years of follow up were included in the analysis. Among males, excess mortality was observed for all cancers (SMR: 1.22, 95% confidence interval [CI]: 1.02 to 1.45) and lung cancer (SMR: 1.59, 95% CI: 1.12 to 2.19). Among females, increased mortality was observed for liver cancer (SMR: 2.05, 95% CI: 1.02 to 3.67). No significant increase was seen in non-cancer-related mortality compared with the general population. Conclusions Carcinogenic risk in humans after exposure to PCBs and PCDFs remains higher among Yusho patients. Our findings suggest the importance of care engagement and optimum management to deal with the burden of Yusho disease.
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ISSN:1476-069X
1476-069X
DOI:10.1186/s12940-020-00680-0