Small molecule metabolites: discovery of biomarkers and therapeutic targets

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and progn...

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Vydané v:Signal transduction and targeted therapy Ročník 8; číslo 1; s. 132 - 37
Hlavní autori: Qiu, Shi, Cai, Ying, Yao, Hong, Lin, Chunsheng, Xie, Yiqiang, Tang, Songqi, Zhang, Aihua
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 20.03.2023
Nature Publishing Group
Predmet:
631/154/1435
631/154/555
631/45/535
Biomarkers
Cancer Research
Cell Biology
Diagnosis
Drug screening
Humans
Internal Medicine
Medicine
Medicine & Public Health
Metabolic networks
Metabolic Networks and Pathways
Metabolic pathways
Metabolism
Metabolites
Metabolome
Metabolomics
Metabolomics - methods
Oncology
Pathology
Phenotypic variations
Prognosis
Review
Review Article
Therapeutic applications
Therapeutic targets
ISSN:2059-3635, 2095-9907, 2059-3635
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Shrnutí:Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolic biomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeutic potentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathways changes as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists have established a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutic target exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-molecule candidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening and treatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.
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ISSN:2059-3635
2095-9907
2059-3635
DOI:10.1038/s41392-023-01399-3