Multidimensional analysis of the host response reveals prognostic and pathogen-driven immune subtypes among adults with sepsis in Uganda

Background The global burden of sepsis is concentrated in sub-Saharan Africa, where severe infections disproportionately affect young, HIV-infected adults and high-burden pathogens are unique. In this context, poor understanding of sepsis immunopathology represents a crucial barrier to development o...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 26; no. 1; pp. 36 - 15
Main Authors:	Cummings, Matthew J., Bakamutumaho, Barnabas, Price, Adam, Owor, Nicholas, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher, Sameroff, Stephen, Tokarz, Rafal, Wong, Wai, Shah, Shivang S., Larsen, Michelle H., Lipkin, W. Ian, Lutwama, Julius J., O’Donnell, Max R.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 08.02.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Africa Biomarkers Chemokines Critical care Critical Care Medicine Development and progression Emergency Medicine Enrollments Health aspects High-throughput nucleotide sequencing HIV Infections Humans Illnesses Immune response Infections Influenza Intensive Ligands Malaria Medical prognosis Medicine Medicine & Public Health Pathogens Patients Prognosis Proteins Risk factors Sepsis Tuberculosis Tumor necrosis factor-TNF Uganda Uganda - epidemiology Variables Uganda United States > US Africa Biomarkers Sepsis Uganda Tuberculosis High-throughput nucleotide sequencing Africa
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X
Online Access:	Get full text
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