Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides

The lissoclimides are unusual succinimide-containing labdane diterpenoids that were reported to be potent cytotoxins. Our short semisynthesis and analogue-oriented synthesis approaches provide a series of lissoclimide natural products and analogues that expand the structure–activity relationships (S...

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Bibliographic Details
Published in:	Nature chemistry Vol. 9; no. 11; pp. 1140 - 1149
Main Authors:	Könst, Zef A., Szklarski, Anne R., Pellegrino, Simone, Michalak, Sharon E., Meyer, Mélanie, Zanette, Camila, Cencic, Regina, Nam, Sangkil, Voora, Vamsee K., Horne, David A., Pelletier, Jerry, Mobley, David L., Yusupova, Gulnara, Yusupov, Marat, Vanderwal, Christopher D.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.11.2017 Springer Nature Nature Publishing Group
Subjects:	631/535/1266 639/638/309/2420 639/638/549/977 Analogs Analytical Chemistry Animals Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Binding sites Biochemistry Biological Products - chemical synthesis Biological Products - chemistry Biological Products - pharmacology Biotechnology Cancer Cell Line, Tumor Cell Proliferation - drug effects Chemistry Chemistry, Multidisciplinary Chemistry/Food Science Computer applications Crystal structure Crystallography, X-Ray Cytotoxins Diterpenes Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology Drug Screening Assays, Antitumor Eukaryotic Initiation Factors - antagonists & inhibitors Eukaryotic Initiation Factors - metabolism Guanine Humans Inhibitors Inorganic Chemistry Life Sciences Metabolites Mice Models, Molecular Molecular Conformation Natural products Organic Chemistry Peptides, Cyclic Physical Chemistry Physical Sciences Protein biosynthesis Protein Biosynthesis - drug effects Protein synthesis Science & Technology Semisynthesis Structure-activity relationships Succinimide Succinimides - chemical synthesis Succinimides - chemistry Succinimides - pharmacology Translation Tumor cell lines CORE DICHLOROLISSOCLIMIDE PROTEIN LACTIMIDOMYCIN CYTOTOXIC DITERPENE ALKALOIDS RIBOSOME
ISSN:	1755-4330, 1755-4349, 1755-4349
Online Access:	Get full text
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