Opportunities and challenges of macrogenetic studies

The rapidly emerging field of macrogenetics focuses on analysing publicly accessible genetic datasets from thousands of species to explore large-scale patterns and predictors of intraspecific genetic variation. Facilitated by advances in evolutionary biology, technology, data infrastructure, statist...

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Vydáno v:Nature reviews. Genetics Ročník 22; číslo 12; s. 791 - 807
Hlavní autoři: Leigh, Deborah M., van Rees, Charles B., Millette, Katie L., Breed, Martin F., Schmidt, Chloé, Bertola, Laura D., Hand, Brian K., Hunter, Margaret E., Jensen, Evelyn L., Kershaw, Francine, Liggins, Libby, Luikart, Gordon, Manel, Stéphanie, Mergeay, Joachim, Miller, Joshua M., Segelbacher, Gernot, Hoban, Sean, Paz-Vinas, Ivan
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.12.2021
Nature Publishing Group
Témata:
631/158
631/208/182
631/208/212/2303
631/208/457/649
Agriculture
Animal Genetics and Genomics
Animals
Biodiversity
Biological diversity
Biomedical and Life Sciences
Biomedicine
Cancer Research
Conservation
Databases, Genetic
Gene Function
Genetic analysis
Genetic diversity
Genetic Techniques
Genetic Variation
Genetics
Genetics, Population
Human Genetics
Humans
Intraspecific genetic variation
Life history
Life Sciences
Phylogeography
Review Article
Workflow
Switzerland
ISSN:1471-0056, 1471-0064, 1471-0064
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Popis
Shrnutí:The rapidly emerging field of macrogenetics focuses on analysing publicly accessible genetic datasets from thousands of species to explore large-scale patterns and predictors of intraspecific genetic variation. Facilitated by advances in evolutionary biology, technology, data infrastructure, statistics and open science, macrogenetics addresses core evolutionary hypotheses (such as disentangling environmental and life-history effects on genetic variation) with a global focus. Yet, there are important, often overlooked, limitations to this approach and best practices need to be considered and adopted if macrogenetics is to continue its exciting trajectory and reach its full potential in fields such as biodiversity monitoring and conservation. Here, we review the history of this rapidly growing field, highlight knowledge gaps and future directions, and provide guidelines for further research. Leigh and colleagues describe the potential of the emerging field of macrogenetics to improve conservation and biodiversity management. Challenges preventing the field from reaching its full promise are highlighted and possible solutions and a framework for future macrogenetic studies are proposed.
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ISSN:1471-0056
1471-0064
1471-0064
DOI:10.1038/s41576-021-00394-0