Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations

The B vitamins are components of one-carbon metabolism (OCM) that contribute to DNA synthesis and methylation. Homocysteine, a by-product of OCM, has been associated with coronary heart disease, stroke and neurological disease. To investigate genetic factors that affect circulating vitamin B6, vitam...

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Vydáno v:	American journal of human genetics Ročník 84; číslo 4; s. 477
Hlavní autoři:	Tanaka, Toshiko, Scheet, Paul, Giusti, Betti, Bandinelli, Stefania, Piras, Maria Grazia, Usala, Gianluca, Lai, Sandra, Mulas, Antonella, Corsi, Anna Maria, Vestrini, Anna, Sofi, Francesco, Gori, Anna Maria, Abbate, Rosanna, Guralnik, Jack, Singleton, Andrew, Abecasis, Goncalo R, Schlessinger, David, Uda, Manuela, Ferrucci, Luigi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.04.2009
Témata:	Adult Aged Aged, 80 and over Alkaline Phosphatase - genetics Female Folic Acid - blood Fucosyltransferases - genetics Galactoside 2-alpha-L-fucosyltransferase Genome-Wide Association Study Homocysteine - blood Humans Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Neoplasm Proteins - genetics Polymorphism, Single Nucleotide Receptors, Cell Surface - genetics Transcobalamins - genetics Vitamin B 12 - blood Vitamin B 6 - blood
ISSN:	1537-6605, 1537-6605
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