Six-minute walk distance in healthy subjects: reference standards from a general population sample

Introduction The 6-min walking distance (6MWD) test is a useful tool to obtain a measure of functional exercise capacity. However, reference equations have been mainly based on selected populations or small samples. The purpose of this study was to determine the reference equations to predict the 6M...

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Vydáno v:Respiratory research Ročník 23; číslo 1; s. 83 - 9
Hlavní autoři: Cazzoletti, Lucia, Zanolin, Maria Elisabetta, Dorelli, Gianluigi, Ferrari, Pietro, Dalle Carbonare, Luca Giuseppe, Crisafulli, Ernesto, Alemayohu, Mulubirhan Assefa, Olivieri, Mario, Verlato, Giuseppe, Ferrari, Marcello
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 05.04.2022
BioMed Central Ltd
Nature Publishing Group
BMC
Témata:
6-min walking test
Adult
Age
Aged
Arthritis
Asthma
Blood pressure
Body Height
Child
Child, Preschool
Contraindications
Diabetes
Exercise
Exercise Test
Female
Females
Function status (activity levels)
General population
Health aspects
Healthy subjects
Healthy Volunteers
Humans
Hypertension
Infant
Male
Males
Medicine
Medicine & Public Health
Middle Aged
Neuromuscular diseases
Physical activity
Physical fitness
Physiological aspects
Pneumology/Respiratory System
Population
Population studies
Questionnaires
Reference Standards
Reference Values
Regression analysis
Regression models
Respiratory diseases
Sleep apnea
Statistical analysis
Values
Variables
Walking
Italy
General population
Healthy subjects
Function status (activity levels)
Reference values
6-min walking test
ISSN:1465-993X, 1465-9921, 1465-993X
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Shrnutí:Introduction The 6-min walking distance (6MWD) test is a useful tool to obtain a measure of functional exercise capacity. However, reference equations have been mainly based on selected populations or small samples. The purpose of this study was to determine the reference equations to predict the 6MWD in a large Italian population sample of healthy adults of a wide age range. Methods In the frame of the multi case–control population-based study Gene Environment Interaction in Respiratory Diseases (GEIRD), we studied 530 healthy subjects: 287 females ranging 21–76 and 243 males ranging 21–78 years of age. We measured 6MWD, demographic and anthropometric data and collected the reported physical activity. A multiple linear regression model for the 6MWD included age, age 2 , height, weight and physical activity for both sex equations. The two-way interaction age-height and age-weight and the quadratic terms of weight and height were also tested for inclusion separately in each model. Results The mean ± SD for 6MWD was 581.4 ± 66.5 m (range 383–800 m) for females and 608.7 ± 80.1 m (range 410–875 m) for males. The reference equations were 6MWD = 8.10*age + 1.61*height cm −0.99*weight kg  + 22.58*active−0.10*age 2  + 222.55 for females (R squared = 0.238) and 6MWD = 26.80*age + 8.46*height cm −0.45*weight kg −2.54*active−0.06*age 2 −0.13*age*height cm −890.18 for males (R squared = 0.159), where “active” is 1 when the subject is physically active, 0 otherwise. Conclusion This study is the first to describe the 6MWD in a large population sample of young, middle aged and elderly healthy Caucasian subjects, and to determine reference equations. These findings will help to improve the evaluation of Italian and European patients with diseases influencing their functional capacity.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1465-993X
1465-9921
1465-993X
DOI:10.1186/s12931-022-02003-y