Long-term exposure to particulate air pollution and brachial artery flow-mediated dilation in the Old Order Amish

Background Atmospheric particulate matter (PM) has been associated with endothelial dysfunction, an early marker of cardiovascular risk. Our aim was to extend this research to a genetically homogenous, geographically stable rural population using location-specific moving-average air pollution exposu...

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Bibliographic Details
Published in:Environmental health Vol. 19; no. 1; pp. 50 - 9
Main Authors: Salimi, Shabnam, Yanosky, Jeff D., Huang, Dina, Montressor-Lopez, Jessica, Vogel, Robert, Reed, Robert M., Mitchell, Braxton D., Puett, Robin C.
Format: Journal Article
Language:English
Published: London BioMed Central 14.05.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Adult
Age
Aged
Aged, 80 and over
Air Pollutants - adverse effects
Air pollution
Amish
Amish - statistics & numerical data
Analysis
Associations
Atherosclerosis
Atmospheric models
Bayesian analysis
Blood pressure
Brachial Artery - drug effects
Brachial Artery - physiology
Cardiovascular diseases
Dilation
Earth and Environmental Science
Endothelial function, Cardiovascular disease
Endothelium
Environment
Environmental Epidemiology
Environmental Exposure - adverse effects
Environmental Health
Estimates
Exposure
Female
Geographic information systems
Health risks
Heart
Humans
Hypertension
Male
Mathematical models
Measurement methods
Middle Aged
Nitric oxide
Occupational Medicine/Industrial Medicine
Oxidative stress
Particulate emissions
Particulate matter
Particulate Matter - adverse effects
Pennsylvania
Pollution index
Polynomials
Population
Public Health
Regional Blood Flow
Regression analysis
Regression models
Remote sensing
Risk factors
Rural Population - statistics & numerical data
Rural populations
Seasons
Shear stress
Smoking
Studies
Ultrasonic imaging
Veins & arteries
Velocity
Viscosity
Young Adult
Pennsylvania
Endothelial function, Cardiovascular disease
Air pollution
Particulate matter
ISSN:1476-069X, 1476-069X
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Summary:Background Atmospheric particulate matter (PM) has been associated with endothelial dysfunction, an early marker of cardiovascular risk. Our aim was to extend this research to a genetically homogenous, geographically stable rural population using location-specific moving-average air pollution exposure estimates indexed to the date of endothelial function measurement. Methods We measured endothelial function using brachial artery flow-mediated dilation (FMD) in 615 community-dwelling healthy Amish participants. Exposures to PM < 2.5 μm (PM 2.5 ) and PM < 10 μm (PM 10 ) were estimated at participants’ residential addresses using previously developed geographic information system-based spatio-temporal models and normalized. Associations between PM exposures and FMD were evaluated using linear mixed-effects regression models, and polynomial distributed lag (PDL) models followed by Bayesian model averaging (BMA) were used to assess response to delayed effects occurring across multiple months. Results Exposure to PM 10 was consistently inversely associated with FMD, with the strongest (most negative) association for a 12-month moving average (− 0.09; 95% CI: − 0.15, − 0.03). Associations with PM 2.5 were also strongest for a 12-month moving average but were weaker than for PM 10 (− 0.07; 95% CI: − 0.13, − 0.09). Associations of PM 2.5 and PM 10 with FMD were somewhat stronger in men than in women, particularly for PM 10 . Conclusions Using location-specific moving-average air pollution exposure estimates, we have shown that 12-month moving-average estimates of PM 2.5 and PM 10 exposure are associated with impaired endothelial function in a rural population.
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ISSN:1476-069X
1476-069X
DOI:10.1186/s12940-020-00593-y