Reshaping the path of vascular cognitive impairment with resistance training: a study protocol for a randomized controlled trial

Background Subcortical ischemic vascular cognitive impairment (SIVCI) is the most common form of vascular cognitive impairment. Importantly, SIVCI is considered the most treatable form of cognitive impairment in older adults, due to its modifiable risk factors such as hypertension, diabetes mellitus...

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Published in:Current controlled trials in cardiovascular medicine Vol. 22; no. 1; pp. 217 - 12
Main Authors: Liu-Ambrose, Teresa, Dao, Elizabeth, Crockett, Rachel A., Barha, Cindy K., Falck, Ryan S., Best, John R., Hsiung, Ging-Yeuk R., Field, Thalia S., Madden, Kenneth M., Alkeridy, Walid A., Boa Sorte Silva, Narlon C., Davis, Jennifer C., ten Brinke, Lisanne F., Doherty, Stephanie, Tam, Roger C.
Format: Journal Article
Language:English
Published: London BioMed Central 18.03.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Aerobics
Alzheimer's disease
Biomedicine
Blood circulation disorders
Brain research
Care and treatment
Cerebrovascular disease
Clinical trials
Cognition disorders
Cognitive ability
Cognitive Function
Consent
Dementia
Executive function
Exercise
Exercise therapy
Health aspects
Health Sciences
Insulin-like growth factors
Magnetic resonance imaging
Medicine
Medicine & Public Health
Mobility
Older people
Physical fitness
Randomized controlled trial
Resistance training
Risk factors
Sarcopenia
Statistics for Life Sciences
Strength training
Stroke
Study Protocol
Testing
Vascular cognitive impairment
Weight training
Canada
Cognitive Function
White matter hyperintensities
Exercise
Vascular cognitive impairment
Resistance training
Mobility
Randomized controlled trial
ISSN:1745-6215, 1745-6215
Online Access:Get full text
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Summary:Background Subcortical ischemic vascular cognitive impairment (SIVCI) is the most common form of vascular cognitive impairment. Importantly, SIVCI is considered the most treatable form of cognitive impairment in older adults, due to its modifiable risk factors such as hypertension, diabetes mellitus, and hypercholesterolemia. Exercise training is a promising intervention to delay the progression of SIVCI, as it actively targets these cardiometabolic risk factors. Despite the demonstrated benefits of resistance training on cognitive function and emerging evidence suggesting resistance training may reduce the progression of white matter hyperintensities (WMHs), research on SIVCI has predominantly focused on the use of aerobic exercise. Thus, the primary aim of this proof-of-concept randomized controlled trial is to investigate the efficacy of a 12-month, twice-weekly progressive resistance training program on cognitive function and WMH progression in adults with SIVCI. We will also assess the efficiency of the intervention. Methods Eighty-eight community-dwelling adults, aged >  55 years, with SIVCI from metropolitan Vancouver will be recruited to participate in this study. SIVCI will be determined by the presence of cognitive impairment (Montreal Cognitive Assessment < 26) and cerebral small vessel disease using computed tomography or magnetic resonance imaging. Participants will be randomly allocated to a twice-weekly exercise program of (1) progressive resistance training or (2) balance and tone training (i.e., active control). The primary outcomes are cognitive function measured by the Alzheimer’s Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-13 with additional cognitive tests) and WMH progression. Discussion The burden of SIVCI is immense, and to our knowledge, this will be the first study to quantify the effect of progressive resistance training on cognitive function and WMH progression among adults with SIVCI. Slowing the rate of cognitive decline and WMH progression could preserve functional independence and quality of life. This could lead to reduced health care costs and avoidance of early institutional care. Trial registration ClinicalTrials.gov NCT02669394 . Registered on February 1, 2016
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ISSN:1745-6215
1745-6215
DOI:10.1186/s13063-021-05156-1