Towards a systematic use of effect biomarkers in population and occupational biomonitoring

•Reliable effect biomarkers are available for most of the relevant MoAs.•Increasing AOP knowledge fosters the use of effect biomarkers in regulatory context.•PBK/D models allow interpretation and simulation of biomarkers of effect.•An inter-regulatory setting of effect-based trigger values is demand...

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Vydáno v:	ENVIRONMENT INTERNATIONAL Ročník 146; s. 106257
Hlavní autoři:	Zare Jeddi, Maryam, Hopf, Nancy B., Viegas, Susana, Price, Anna Bal, Paini, Alicia, van Thriel, Christoph, Benfenati, Emilio, Ndaw, Sophie, Bessems, Jos, Behnisch, Peter A., Leng, Gabriele, Duca, Radu-Corneliu, Verhagen, Hans, Cubadda, Francesco, Brennan, Lorraine, Ali, Imran, David, Arthur, Mustieles, Vicente, Fernandez, Mariana F., Louro, Henriqueta, Pasanen-Kase, Robert
Médium:	Journal Article Publikace
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Ltd 01.01.2021 Elsevier
Témata:	adverse outcome pathways Adverse outcome pathways (AOP) Biological Monitoring Biomarkers Biomonitoring computer simulation environment Environmental Exposure - analysis Environmental Monitoring Europe exposure assessment Exposure science genotoxicity health effects assessments human health Humans Life Sciences Mixture assessment Physiologically based pharmacokinetic (PBPK) risk Risk Assessment risk assessment process Europe IOELV Biomonitoring PoD DNT MDA EFSA DNEL HBM OECD CMD WPEA EC OBEL Physiologically based pharmacokinetic (PBPK) WHO CAD MIE Biological EQ AO IUCLID Adverse outcome pathways (AOP) ECHA OEL KER Effect WPHA Mixture assessment MoA PPE AOP-KB PBD modelling HBM4EU BBLV Risk assessment SCOEL OBL KE EGMAST AOP B-Pb ISO ADME BOELV OSH Exposure science REACH RMM RAC ACGIH PBK modelling SEGs ISES
ISSN:	0160-4120, 1873-6750, 1873-6750
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