The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis

Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer progression, but the underlying mechanisms are poorly understood. The purpose of this study was to elucidate mechanisms by which PXN affects cancer growth and progression, which we addressed using cancer p...

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Veröffentlicht in:	Oncogene Jg. 40; H. 2; S. 384 - 395
Hauptverfasser:	Noh, Kyunghee, Bach, Duc-Hiep, Choi, Hyun-Jin, Kim, Mark S., Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Cho, Min-Soon, Bayraktar, Emine, Rodriguez-Aguayo, Cristian, Dasari, Santosh K., Stur, Elaine, Mangala, Lingegowda S., Lopez-Berestein, Gabriel, Sood, Anil K.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 14.01.2021 Nature Publishing Group
Schlagworte:	38/1 42/89 631/67/1517/1709 631/67/2328 Angiogenesis Animal models Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Carcinogenesis Carrier proteins Cell Biology Cell Nucleus - metabolism Cell Proliferation Disease Progression Endothelial cells Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Human Genetics Humans Internal Medicine Localization Medicine Medicine & Public Health Metastases Mice Mice, Nude Neovascularization Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Oncology Ovarian cancer Ovarian Neoplasms - blood supply Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Paxillin Paxillin - antagonists & inhibitors Paxillin - genetics Paxillin - metabolism Prognosis src-Family Kinases - genetics src-Family Kinases - metabolism Survival Rate Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - metabolism Transcription Tumor cell lines Tumor Cells, Cultured Xenograft Model Antitumor Assays United States
ISSN:	0950-9232, 1476-5594, 1476-5594
Online-Zugang:	Volltext
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