Month of birth and the risk of developing type 1 diabetes among children in the Swedish national Better Diabetes Diagnosis Study

Aim Previous studies have reported an association between month of birth and incidence of type 1 diabetes. Using population‐based data, including almost all newly diagnosed children with type 1 diabetes in Sweden, we tested whether month of birth influences the risk of type 1 diabetes. Methods For 8...

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Vydáno v:Acta Paediatrica Ročník 111; číslo 12; s. 2378 - 2383
Hlavní autoři: Hedlund, Emma, Ludvigsson, Johnny, Elding Larsson, Helena, Forsander, Gun, Ivarsson, Sten, Marcus, Claude, Samuelsson, Ulf, Persson, Martina, Carlsson, Annelie
Médium: Journal Article
Jazyk:angličtina
Vydáno: Norway Wiley Subscription Services, Inc 01.12.2022
John Wiley and Sons Inc
Témata:
Autoantibodies
autoimmunity
Birth
birth pattern
Child
Children
Clinical Medicine
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - epidemiology
Diagnosis
differs
Endocrinology and Diabetes
Endokrinologi och diabetes
enterovirus infection
Female
Genotype
Genotypes
Histocompatibility antigen HLA
HLA-DQ alleles
HLA-DQ Antigens - genetics
Humans
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
mellitus
onset
Original
Original & Brief Reports
Pediatrics
Pediatrik
seasonality
seroconversion
Sweden - epidemiology
type 1
type 1 diabetes
Sweden
birth pattern
type 1 diabetes
autoantibodies
seasonality
HLA-DQ alleles
ISSN:0803-5253, 1651-2227, 1651-2227
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Shrnutí:Aim Previous studies have reported an association between month of birth and incidence of type 1 diabetes. Using population‐based data, including almost all newly diagnosed children with type 1 diabetes in Sweden, we tested whether month of birth influences the risk of type 1 diabetes. Methods For 8761 children diagnosed with type 1 diabetes between May 2005 and December 2016 in the Better Diabetes Diagnosis study, month of birth, sex and age were compared. Human leucocyte antigen (HLA) genotype and autoantibodies at diagnosis were analysed for a subset of the cohort (n = 3647). Comparisons with the general population used data from Statistics Sweden. Results We found no association between month of birth or season and the incidence of type 1 diabetes in the cohort as a whole. However, boys diagnosed before 5 years were more often born in May (p = 0.004). We found no correlation between month of birth and HLA or antibodies. Conclusion In this large nationwide study, the impact of month of birth on type 1 diabetes diagnosis was weak, except for boys diagnosed before 5 years of age, who were more likely born in May. This may suggest different triggers for different subgroups of patients with type 1 diabetes.
Bibliografie:Funding information
The BDD study has received funding from Barndiabetesfonden (Swedish Child Diabetes Foundation) and Region Skåne's research and development fund.
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ISSN:0803-5253
1651-2227
1651-2227
DOI:10.1111/apa.16426