Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error‐free, and th...

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Veröffentlicht in:	The EMBO journal Jg. 28; H. 4; S. 383 - 393
Hauptverfasser:	Shachar, Sigal, Ziv, Omer, Avkin, Sharon, Adar, Sheera, Wittschieben, John, Reißner, Thomas, Chaney, Stephen, Friedberg, Errol C, Wang, Zhigang, Carell, Thomas, Geacintov, Nicholas, Livneh, Zvi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Chichester, UK John Wiley & Sons, Ltd 18.02.2009 Nature Publishing Group UK Springer Nature B.V Nature Publishing Group
Schlagworte:	Animals carcinogenesis Catalysis Cell Line, Tumor Cellular biology Deoxyribonucleic acid Dimerization DNA DNA - chemistry DNA - metabolism DNA Damage DNA polymerase DNA repair DNA Replication DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - metabolism Epistasis, Genetic Genomics Humans Kinetics lesion bypass Lesions Mammals Mice Molecular biology Mutagenesis Pyrimidine Dimers - chemistry RNA, Small Interfering - metabolism Xeroderma Pigmentosum Group A Protein - metabolism carcinogenesis DNA repair mutagenesis DNA damage lesion bypass
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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