Genetic architecture of host proteins involved in SARS-CoV-2 infection

Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identify new or repurpose existing drugs targeting those proteins. We present a genetic discovery study of 179 such host proteins among 10,708 indivi...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 6397 - 14
Main Authors:	Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Raffler, Johannes, Kerrison, Nicola D., Oerton, Erin, Auyeung, Victoria P. W., Luan, Jian’an, Finan, Chris, Casas, Juan P., Ostroff, Rachel, Williams, Steve A., Kastenmüller, Gabi, Ralser, Markus, Gamazon, Eric R., Wareham, Nicholas J., Hingorani, Aroon D., Langenberg, Claudia
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.12.2020 Nature Publishing Group Nature Portfolio
Subjects:	45 45/61 631/208 692/53 82/80 ABO Blood-Group System - metabolism Aptamers Aptamers, Peptide - blood Aptamers, Peptide - metabolism Blood Coagulation Coronaviruses COVID-19 COVID-19 - genetics COVID-19 - virology Deoxyribonucleic acid DNA Drug delivery Drug Delivery Systems Drug development Female Gene Expression Regulation Gene mapping Genetic diversity Genetic variance Host-Derived Cellular Factors - metabolism Host-Pathogen Interactions - genetics Humanities and Social Sciences Humans Immune response Immunosuppressive agents Internet Interrogation Male Middle Aged multidisciplinary Nucleotide sequence Proteins Proteins - genetics Quantitative trait loci Quantitative Trait Loci - genetics SARS-CoV-2 - physiology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Therapeutic targets Viral diseases
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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