High grade serous ovarian carcinomas originate in the fallopian tube

High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy n...

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Veröffentlicht in:	Nature communications Jg. 8; H. 1; S. 1093 - 11
Hauptverfasser:	Labidi-Galy, S. Intidhar, Papp, Eniko, Hallberg, Dorothy, Niknafs, Noushin, Adleff, Vilmos, Noe, Michael, Bhattacharya, Rohit, Novak, Marian, Jones, Siân, Phallen, Jillian, Hruban, Carolyn A., Hirsch, Michelle S., Lin, Douglas I., Schwartz, Lauren, Maire, Cecile L., Tille, Jean-Christophe, Bowden, Michaela, Ayhan, Ayse, Wood, Laura D., Scharpf, Robert B., Kurman, Robert, Wang, Tian-Li, Shih, Ie-Ming, Karchin, Rachel, Drapkin, Ronny, Velculescu, Victor E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 23.10.2017 Nature Publishing Group Nature Portfolio
Schlagworte:	631/67/1517/1709 631/67/69 Aberration Alleles BRCA1 protein BRCA2 protein Breast cancer Cancer Copy number Cystadenocarcinoma, Serous - genetics DNA Copy Number Variations - genetics Etiology Evolution Fallopian tube Fallopian Tube Neoplasms - metabolism Fallopian Tube Neoplasms - pathology Fallopian Tubes - metabolism Fallopian Tubes - pathology Female Genital cancers Gynecological cancer Humanities and Social Sciences Humans Immunohistochemistry Laser Capture Microdissection Lesions Metastases Metastasis multidisciplinary Neoplasms, Cystic, Mucinous, and Serous - metabolism Neoplasms, Cystic, Mucinous, and Serous - pathology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics p53 Protein Patients PTEN protein Science Science (multidisciplinary) Signatures
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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