TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate—a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)—is stabilise...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 1274 - 16
Main Authors:	Fielden, John, Wiseman, Katherine, Torrecilla, Ignacio, Li, Shudong, Hume, Samuel, Chiang, Shih-Chieh, Ruggiano, Annamaria, Narayan Singh, Abhay, Freire, Raimundo, Hassanieh, Sylvana, Domingo, Enric, Vendrell, Iolanda, Fischer, Roman, Kessler, Benedikt M., Maughan, Timothy S., El-Khamisy, Sherif F., Ramadan, Kristijan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.03.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/109 13/31 14/63 38 631/45/147 631/80/474 82/80 82/83 Adducts Adenosine triphosphatase Adenosine Triphosphatases - metabolism Amino Acid Sequence Cell Line Chemotherapy Cytotoxicity Deoxyribonucleic acid DNA DNA adducts DNA Adducts - metabolism DNA biosynthesis DNA damage DNA Repair DNA Replication DNA Topoisomerases, Type I - metabolism DNA-Binding Proteins - metabolism Epistasis, Genetic Genomes Genomic instability Humanities and Social Sciences Humans Membrane Proteins - chemistry Membrane Proteins - metabolism Metalloproteinase multidisciplinary Neurological diseases Nuclear Proteins - metabolism Phosphodiesterase Phosphoric Diester Hydrolases - metabolism Proteolysis Repair Replication Replication forks Science Science (multidisciplinary) Single-stranded DNA SUMO protein SUMO-1 Protein - metabolism Sumoylation Topology Transcription Tyrosine
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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