Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report...

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Veröffentlicht in:Nature communications Jg. 11; H. 1; S. 119 - 9
Hauptverfasser: Kim, Kayoung, Kim, Min-Ji, Kim, Da Won, Kim, Su Yeong, Park, Steve, Park, Chan Beum
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 08.01.2020
Nature Publishing Group
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Accuracy
Alignment
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer's disease
Amyloid beta-Peptides - blood
Biomarkers
Biomarkers - blood
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Blood
Blood plasma
Coefficient of variation
Diagnosis
Humanities and Social Sciences
Humans
Low concentrations
Medical imaging
Middle Aged
multidisciplinary
Nanotechnology
Nanotubes
Nanotubes, Carbon - chemistry
Neurodegenerative diseases
Neuroimaging
Plasma
Science
Science (multidisciplinary)
Selectivity
Sensitivity
Sensor arrays
Sensors
Single wall carbon nanotubes
Tau protein
tau Proteins - blood
ISSN:2041-1723, 2041-1723
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Abstract Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau 181 , Aβ 42 , and Aβ 40 ) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ 42 , p-tau 181 /Aβ 42 , and Aβ 42 /Aβ 40 in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%. Detection of Alzheimer’s disease (AD) biomarkers from patients’ blood is challenging because these are present in very low concentrations in the plasma. Here the authors develop a sensor array of densely aligned single-walled carbon nanotubes for clinically accurate detection of femtomolar AD biomarkers in human plasma samples.
AbstractList Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau 181 , Aβ 42 , and Aβ 40 ) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ 42 , p-tau 181 /Aβ 42 , and Aβ 42 /Aβ 40 in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%. Detection of Alzheimer’s disease (AD) biomarkers from patients’ blood is challenging because these are present in very low concentrations in the plasma. Here the authors develop a sensor array of densely aligned single-walled carbon nanotubes for clinically accurate detection of femtomolar AD biomarkers in human plasma samples.
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau181, Aβ42, and Aβ40) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ42, p-tau181/Aβ42, and Aβ42/Aβ40 in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%. Detection of Alzheimer’s disease (AD) biomarkers from patients’ blood is challenging because these are present in very low concentrations in the plasma. Here the authors develop a sensor array of densely aligned single-walled carbon nanotubes for clinically accurate detection of femtomolar AD biomarkers in human plasma samples.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau181, Aβ42, and Aβ40) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ42, p-tau181/Aβ42, and Aβ42/Aβ40 in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%.Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau181, Aβ42, and Aβ40) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ42, p-tau181/Aβ42, and Aβ42/Aβ40 in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%.
Detection of Alzheimer’s disease (AD) biomarkers from patients’ blood is challenging because these are present in very low concentrations in the plasma. Here the authors develop a sensor array of densely aligned single-walled carbon nanotubes for clinically accurate detection of femtomolar AD biomarkers in human plasma samples.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau , Aβ , and Aβ ) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ , p-tau /Aβ , and Aβ /Aβ in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%.
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau 181 , Aβ 42 , and Aβ 40 ) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ 42 , p-tau 181 /Aβ 42 , and Aβ 42 /Aβ 40 in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%.
ArticleNumber 119
Author Kim, Min-Ji
Kim, Da Won
Kim, Su Yeong
Kim, Kayoung
Park, Chan Beum
Park, Steve
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  surname: Park
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  email: parkcb@kaist.ac.kr
  organization: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31913282$$D View this record in MEDLINE/PubMed
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NakamuraAHigh performance plasma amyloid-β biomarkers for Alzheimer’s diseaseNature20185542492018Natur.554..249N1:CAS:528:DC%2BC1cXitVaiur8%3D10.1038/nature25456
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JanelidzeSPlasma β-amyloid in Alzheimer’s disease and vascular diseaseSci. Rep.201662016NatSR...626801J1:CAS:528:DC%2BC28XptVWgtbc%3D10.1038/srep26801
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OhJA carbon nanotube metal semiconductor field effect transistor-based biosensor for detection of amyloid-beta in human serumBiosens. Bioelectron.2013503453501:CAS:528:DC%2BC3sXhsVWru7nE10.1016/j.bios.2013.07.004
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SwetsJAMeasuring the accuracy of diagnostic systemsScience198824012851988Sci...240.1285S9654961:STN:280:DyaL1c3jsF2jtQ%3D%3D10.1126/science.3287615
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CZJ Lim (13901_CR36) 2019; 10
X Li (13901_CR18) 2007; 129
T Skillbäck (13901_CR38) 2015; 138
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FN Ishikawa (13901_CR21) 2010; 4
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VB Gupta (13901_CR13) 2013; 5
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K Blennow (13901_CR8) 2015; 11
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N Rifai (13901_CR30) 2006; 24
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JA Swets (13901_CR29) 1988; 240
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Snippet Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease,...
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease,...
Detection of Alzheimer’s disease (AD) biomarkers from patients’ blood is challenging because these are present in very low concentrations in the plasma. Here...
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SubjectTerms 147/135
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631/61/350/59
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82/1
9/10
Accuracy
Alignment
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer's disease
Amyloid beta-Peptides - blood
Biomarkers
Biomarkers - blood
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Blood
Blood plasma
Coefficient of variation
Diagnosis
Humanities and Social Sciences
Humans
Low concentrations
Medical imaging
Middle Aged
multidisciplinary
Nanotechnology
Nanotubes
Nanotubes, Carbon - chemistry
Neurodegenerative diseases
Neuroimaging
Plasma
Science
Science (multidisciplinary)
Selectivity
Sensitivity
Sensor arrays
Sensors
Single wall carbon nanotubes
Tau protein
tau Proteins - blood
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Title Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma
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