Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice

Temporal and spatial-specific regulation of pluripotency networks is largely dependent on the precise modifications of core transcription factors. Misregulation of glutamylation is implicated in severe physiological abnormalities. However, how glutamylation regulates cell reprogramming and pluripote...

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Veröffentlicht in:	Nature communications Jg. 9; H. 1; S. 1261 - 16
Hauptverfasser:	Ye, Buqing, Liu, Benyu, Hao, Lu, Zhu, Xiaoxiao, Yang, Liuliu, Wang, Shuo, Xia, Pengyan, Du, Ying, Meng, Shu, Huang, Guanling, Qin, Xiwen, Wang, Yanying, Yan, Xinlong, Li, Chong, Hao, Junfeng, Zhu, Pingping, He, Luyun, Tian, Yong, Fan, Zusen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 28.03.2018 Nature Publishing Group Nature Portfolio
Schlagworte:	13 13/100 14 14/19 38 38/88 42/41 631/136/2444 631/136/532/2064/2158 631/136/532/2435 631/337/458 82/58 Abnormalities Animals Carboxypeptidases - deficiency Cell Differentiation Cellular Reprogramming Clonal deletion Embryo cells Embryogenesis Embryonic growth stage Embryonic Stem Cells - cytology Female Fibroblasts - cytology Gene Deletion Gene Expression Regulation, Developmental Gene Knock-In Techniques Glutamine - chemistry HEK293 Cells Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology KLF4 protein Kruppel-Like Transcription Factors - metabolism Lethality Lysine Mice multidisciplinary Nerve Tissue Proteins - deficiency Peptide Synthases - metabolism Peptides - chemistry Physiological effects Pluripotency Science Science (multidisciplinary) Stem cell transplantation Stem cells Transcription factors Tubulin Tyrosine Ubiquitination
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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