RNA-based therapeutics: an overview and prospectus

The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto “undruggable” proteins, transcripts and genes, thus potentially broadening the therapeutic targets. Several RNA-based medications have been appr...

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Veröffentlicht in:Cell death & disease Jg. 13; H. 7; S. 644 - 15
Hauptverfasser: Zhu, Yiran, Zhu, Liyuan, Wang, Xian, Jin, Hongchuan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 23.07.2022
Springer Nature B.V
Nature Publishing Group
Schlagworte:
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631/61/391/1914
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Antibodies
Binding sites
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Clinical trials
Disease
Drugs
Enzymes
Gene expression
Genomes
Immunology
Life Sciences
Medical research
MicroRNAs
Proteins
Review
Review Article
Ribonucleic acid
RNA
RNA Interference
RNA, Small Interfering - genetics
Therapeutic targets
ISSN:2041-4889, 2041-4889
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto “undruggable” proteins, transcripts and genes, thus potentially broadening the therapeutic targets. Several RNA-based medications have been approved for clinical use, while others are still under investigation or preclinical trials. Various techniques have been explored to promote RNA intracellular trafficking and metabolic stability, despite significant challenges in developing RNA-based therapeutics. In this review, the mechanisms of action, challenges, solutions, and clinical application of RNA-based therapeutics have been comprehensively summarized.
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ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-022-05075-2