c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment

The MYC oncogenic family is dysregulated in diverse tumors which is generally linked to the poor prognosis of tumors. The members in MYC family are transcription factors which are responsible for the regulation of various genes expression. Among them, c-MYC is closely related to the progression of t...

Full description

Saved in:
Bibliographic Details
Published in:Cell communication and signaling Vol. 21; no. 1; pp. 28 - 8
Main Authors: Gao, Fang-yan, Li, Xin-tong, Xu, Kun, Wang, Run-tian, Guan, Xiao-xiang
Format: Journal Article
Language:English
Published: London BioMed Central 31.01.2023
Springer Nature B.V
BMC
Subjects:
Angiogenesis
Biomedical and Life Sciences
Blood vessels
Breast cancer
Breast Neoplasms
c-MYC
c-Myc protein
Cancer-Associated Fibroblasts
Cell Biology
Cell cycle
Cell growth
Crosstalk
Cytokines and Growth Factors
Endothelial Cells
Fibroblasts
Gene Expression
Gene regulation
Genes, myc
Immune Evasion
Leukocyte migration
Life Sciences
Lymphocytes
Macrophages
Metastasis
Myc protein
Prognosis
Protein-Ligand Interactions
Receptors
Review
Stem cells
Suppressor cells
Transcription factors
Tumor Microenvironment
Tumor-infiltrating lymphocytes
Tumors
Vascular endothelial growth factor
Breast cancer
Tumor microenvironment
c-MYC
Crosstalk
ISSN:1478-811X, 1478-811X
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The MYC oncogenic family is dysregulated in diverse tumors which is generally linked to the poor prognosis of tumors. The members in MYC family are transcription factors which are responsible for the regulation of various genes expression. Among them, c-MYC is closely related to the progression of tumors. Furthermore, c-MYC aberrations is tightly associated with the prevalence of breast cancer. Tumor microenvironment (TME) is composed of many different types of cellular and non-cellular factors, mainly including cancer-associated fibroblasts, tumor-associated macrophages, vascular endothelial cells, myeloid-derived suppressor cells and immune cells, all of which can affect the diagnosis, prognosis, and therapeutic efficacy of breast cancer. Importantly, the biological processes occurred in TME, such as angiogenesis, immune evasion, invasion, migration, and the recruition of stromal and tumor-infiltrating cells are under the modulation of c-MYC. These findings indicated that c-MYC serves as a critical regulator of TME. Here, we aimed to summarize and review the relevant research, thus to clarify c-MYC is a key mediator between breast cancer cells and TME. DVLPdmoXAPbqrJeJ-uvGmg Video Abstract
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Undefined-1
ObjectType-Feature-3
ObjectType-Review-4
content type line 23
ISSN:1478-811X
1478-811X
DOI:10.1186/s12964-023-01043-1