Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

Fibrotic skin disease represents a major global healthcare burden, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts are found to be heterogeneous in multiple fibrotic diseases, but fibroblast heterogeneity in fibrotic skin diseases is not...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 3709 - 16
Main Authors:	Deng, Cheng-Cheng, Hu, Yong-Fei, Zhu, Ding-Heng, Cheng, Qing, Gu, Jing-Jing, Feng, Qing-Lan, Zhang, Li-Xue, Xu, Ying-Ping, Wang, Dong, Rong, Zhili, Yang, Bin
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.06.2021 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/21 13/31 13/51 14/19 38/39 38/77 45/91 631/114 631/1647/514/1949 631/61/514/1949 631/80/304 692/1807/1812 Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Collagen Collagen - genetics Collagen - metabolism Disease Extracellular matrix Extracellular Matrix - genetics Extracellular Matrix - metabolism Extracellular Matrix - pathology Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Gene Expression Regulation - genetics Gene Ontology Global health Heterogeneity Humanities and Social Sciences Humans Inflammation Keloid - genetics Keloid - metabolism Keloid - pathology Ligands Mesenchyme Mesoderm - cytology Mesoderm - metabolism Mesoderm - pathology multidisciplinary Pathogenesis RNA-Seq Science Science (multidisciplinary) Scleroderma Scleroderma, Systemic - genetics Scleroderma, Systemic - metabolism Scleroderma, Systemic - pathology Single-Cell Analysis Skin diseases Skin Diseases - genetics Skin Diseases - metabolism Skin Diseases - pathology Subpopulations
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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