Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4

Obesity, a prevalent condition in adults and children, impairs bone marrow (BM) function. However, the underlying mechanisms are unclear. Here, we show that obese mice exhibit poor emergency immune responses in a toll-like receptor 4 (TLR4)-dependent manner. Canonical myeloid genes ( Csf1r , Spi1 ,...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 708 - 11
Main Authors:	Liu, Ailing, Chen, Minhui, Kumar, Rashmi, Stefanovic-Racic, Maja, O’Doherty, Robert M., Ding, Ying, Jahnen-Dechent, Willi, Borghesi, Lisa
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.02.2018 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/31 38/39 38/77 631/250/232/2058 631/250/232/2059 631/250/24/2510 631/443/319/1642/393 64/60 Adoptive Transfer Adults Animals Bone marrow Bone Marrow - physiopathology Children Emergency response Endotoxemia Fetuses Genes Hematopoiesis Hematopoietic Stem Cells - metabolism Hemopoiesis High fat diet Humanities and Social Sciences Immune response Immune system Lipopolysaccharides Male Mice Mice, Inbred C57BL multidisciplinary Obesity Obesity - immunology Obesity - metabolism Obesity - physiopathology Precursors Proteins Rodents Runx1 protein Science Science (multidisciplinary) TLR4 protein Toll-Like Receptor 4 - physiology Toll-like receptors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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