Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

In Mendelian randomization (MR) analysis, variants that exert horizontal pleiotropy are typically treated as a nuisance. However, they could be valuable in identifying alternative pathways to the traits under investigation. Here, we develop MR-TRYX, a framework that exploits horizontal pleiotropy to...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 1010 - 13
Main Authors:	Cho, Yoonsu, Haycock, Philip C., Sanderson, Eleanor, Gaunt, Tom R., Zheng, Jie, Morris, Andrew P., Davey Smith, George, Hemani, Gibran
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 21.02.2020 Nature Publishing Group Nature Portfolio
Subjects:	45 45/43 631/114/2415 631/208/205 692/308/174 692/308/2056 Causality Computer Simulation Data analysis Databases, Genetic Disease - genetics Estimates Exposure Genetic Pleiotropy Genetic Variation Genome-Wide Association Study Heterogeneity Humanities and Social Sciences Humans Influence Mendelian Randomization Analysis Methods Models, Genetic multidisciplinary Outliers (statistics) Phenotype Pleiotropy Polymorphism, Single Nucleotide Randomization Risk analysis Risk Factors Science Science (multidisciplinary) Simulation
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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