Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

In Mendelian randomization (MR) analysis, variants that exert horizontal pleiotropy are typically treated as a nuisance. However, they could be valuable in identifying alternative pathways to the traits under investigation. Here, we develop MR-TRYX, a framework that exploits horizontal pleiotropy to...

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Vydáno v:	Nature communications Ročník 11; číslo 1; s. 1010 - 13
Hlavní autoři:	Cho, Yoonsu, Haycock, Philip C., Sanderson, Eleanor, Gaunt, Tom R., Zheng, Jie, Morris, Andrew P., Davey Smith, George, Hemani, Gibran
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 21.02.2020 Nature Publishing Group Nature Portfolio
Témata:	45 45/43 631/114/2415 631/208/205 692/308/174 692/308/2056 Causality Computer Simulation Data analysis Databases, Genetic Disease - genetics Estimates Exposure Genetic Pleiotropy Genetic Variation Genome-Wide Association Study Heterogeneity Humanities and Social Sciences Humans Influence Mendelian Randomization Analysis Methods Models, Genetic multidisciplinary Outliers (statistics) Phenotype Pleiotropy Polymorphism, Single Nucleotide Randomization Risk analysis Risk Factors Science Science (multidisciplinary) Simulation
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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