Advances in the pathogenesis of psoriasis: from keratinocyte perspective

Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevan...

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Bibliographic Details
Published in:Cell death & disease Vol. 13; no. 1; pp. 81 - 13
Main Authors: Zhou, Xue, Chen, Youdong, Cui, Lian, Shi, Yuling, Guo, Chunyuan
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 24.01.2022
Springer Nature B.V
Nature Publishing Group
Subjects:
13/21
631/80/304
692/699/249
82/80
Antibodies
Antimicrobial peptides
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell signaling
Cytokines - metabolism
Dermatitis - metabolism
Humans
Hyperplasia
Immunology
Keratinocytes
Keratinocytes - metabolism
Life Sciences
Pathogenesis
Psoriasis
Psoriasis - metabolism
Review
Review Article
Signal Transduction
Skin diseases
Transcription factors
ISSN:2041-4889, 2041-4889
Online Access:Get full text
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Summary:Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis.
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ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-022-04523-3