An epigenome-wide association study of metabolic syndrome and its components

The role of metabolic syndrome (MetS) as a preceding metabolic state for type 2 diabetes and cardiovascular disease is widely recognised. To accumulate knowledge of the pathological mechanisms behind the condition at the methylation level, we conducted an epigenome-wide association study (EWAS) of M...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports Vol. 10; no. 1; pp. 20567 - 12
Main Authors: Nuotio, Marja-Liisa, Pervjakova, Natalia, Joensuu, Anni, Karhunen, Ville, Hiekkalinna, Tero, Milani, Lili, Kettunen, Johannes, Järvelin, Marjo-Riitta, Jousilahti, Pekka, Metspalu, Andres, Salomaa, Veikko, Kristiansson, Kati, Perola, Markus
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 25.11.2020
Nature Publishing Group
Nature Portfolio
Subjects:
631/208/176/1988
692/308/2056
Adult
Aged
ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics
Cardiovascular diseases
Carrier Proteins - genetics
Chromosome 1
Chromosome 21
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - genetics
DNA methylation
DNA Methylation - genetics
Epigenesis, Genetic - genetics
Epigenome - genetics
Epigenomics - methods
Female
Finland - epidemiology
Genome - genetics
Genome-Wide Association Study - methods
Genomes
Glucose
Glucose - metabolism
High density lipoprotein
Humanities and Social Sciences
Humans
Lipid metabolism
Lipid Metabolism - genetics
Lipids - genetics
Male
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - genetics
Metabolic Syndrome - metabolism
Methylation
Middle Aged
multidisciplinary
Polymorphism, Single Nucleotide - genetics
Science
Science (multidisciplinary)
Triglycerides
White People - genetics
Finland
ISSN:2045-2322, 2045-2322
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of metabolic syndrome (MetS) as a preceding metabolic state for type 2 diabetes and cardiovascular disease is widely recognised. To accumulate knowledge of the pathological mechanisms behind the condition at the methylation level, we conducted an epigenome-wide association study (EWAS) of MetS and its components, testing 1187 individuals of European ancestry for approximately 470 000 methylation sites throughout the genome. Methylation site cg19693031 in gene TXNIP —previously associated with type 2 diabetes, glucose and lipid metabolism, associated with fasting glucose level ( P  = 1.80 × 10 −8 ). Cg06500161 in gene ABCG1 associated both with serum triglycerides ( P  = 5.36 × 10 −9 ) and waist circumference ( P  = 5.21 × 10 −9 ). The previously identified type 2 diabetes–associated locus cg08309687 in chromosome 21 associated with waist circumference for the first time ( P  = 2.24 × 10 −7 ). Furthermore, a novel HDL association with cg17901584 in chromosome 1 was identified ( P  = 7.81 × 10 −8 ). Our study supports previous genetic studies of MetS, finding that lipid metabolism plays a key role in pathology of the syndrome. We provide evidence regarding a close interplay with glucose metabolism. Finally, we suggest that in attempts to identify methylation loci linking separate MetS components, cg19693031 appears to represent a strong candidate.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-77506-z