Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital

Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 A...

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Vydané v:	Nature communications Ročník 11; číslo 1; s. 3500 - 9
Hlavní autori:	Garcia-Basteiro, Alberto L., Moncunill, Gemma, Tortajada, Marta, Vidal, Marta, Guinovart, Caterina, Jiménez, Alfons, Santano, Rebeca, Sanz, Sergi, Méndez, Susana, Llupià, Anna, Aguilar, Ruth, Alonso, Selena, Barrios, Diana, Carolis, Carlo, Cisteró, Pau, Chóliz, Eugenia, Cruz, Angeline, Fochs, Silvia, Jairoce, Chenjerai, Hecht, Jochen, Lamoglia, Montserrat, Martínez, Mikel J., Mitchell, Robert A., Ortega, Natalia, Pey, Nuria, Puyol, Laura, Ribes, Marta, Rosell, Neus, Sotomayor, Patricia, Torres, Sara, Williams, Sarah, Barroso, Sonia, Vilella, Anna, Muñoz, José, Trilla, Antoni, Varela, Pilar, Mayor, Alfredo, Dobaño, Carlota
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 08.07.2020 Nature Publishing Group Nature Portfolio
Predmet:	49/1 631/250/2152/2153/1291 631/326/596/4130 692/308/174 692/699/255/2514 Adult Antibodies Antibodies, Viral - blood Asymptomatic Infections - epidemiology Betacoronavirus - genetics Betacoronavirus - immunology Betacoronavirus - isolation & purification Coronavirus Infections - blood Coronavirus Infections - diagnosis Coronavirus Infections - epidemiology Coronaviruses COVID-19 Female Health care Health Personnel Humanities and Social Sciences Humans Immunoglobulin A Immunoglobulin G Immunoglobulin M Infections Male Medical personnel Middle Aged multidisciplinary Occupational Health Pandemics Pneumonia, Viral - blood Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Risk Factors RNA, Viral - blood SARS-CoV-2 Science Science (multidisciplinary) Seroepidemiologic Studies Serology Severe acute respiratory syndrome coronavirus 2 Spain - epidemiology Viral diseases Spain
ISSN:	2041-1723, 2041-1723
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Shrnutí:	Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%, 95% CI: 7.1–12.0) were seropositive for IgM and/or IgG and/or IgA against SARS-CoV-2. The cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) was 11.2% (65/578, 95% CI: 8.8–14.1). Among those with evidence of past or current infection, 40.0% (26/65) had not been previously diagnosed with COVID-19. Here we report a relatively low seroprevalence of antibodies among HCW at the peak of the COVID-19 epidemic in Spain. A large proportion of HCW with past or present infection had not been previously diagnosed with COVID-19, which calls for active periodic rRT-PCR testing in hospital settings. Health care workers (HCW) are a high-risk population for SARS-CoV-2 infection. Here, the authors determine seroprevalence against SARS-CoV-2 in HCWs of a large Spanish reference hospital and find a cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) of 11%.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-020-17318-x