DNA–protein crosslink proteases in genome stability

Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. Research in the past several years indicates that cells possess dedicated enzymes, known as DPC proteases,...

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Bibliographic Details
Published in:	Communications biology Vol. 4; no. 1; p. 11
Main Authors:	Ruggiano, Annamaria, Ramadan, Kristijan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.01.2021 Nature Publishing Group Nature Portfolio
Subjects:	631/337/1427 631/45/468 631/67/68 Aspartic Acid Proteases - metabolism Biology Biomedical and Life Sciences Deoxyribonucleic acid DNA DNA biosynthesis DNA Damage DNA repair DNA Replication DNA-Binding Proteins - metabolism Genomes Genomic Instability Histones Humans Life Sciences Nuclear Proteins - metabolism Protein Processing, Post-Translational Proteins Proteolysis Receptors, Virus - metabolism Recombination Replication Review Review Article Transcription
ISSN:	2399-3642, 2399-3642
Online Access:	Get full text
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