DNA–protein crosslink proteases in genome stability

Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. Research in the past several years indicates that cells possess dedicated enzymes, known as DPC proteases,...

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Bibliographic Details
Published in:Communications biology Vol. 4; no. 1; p. 11
Main Authors: Ruggiano, Annamaria, Ramadan, Kristijan
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 04.01.2021
Nature Publishing Group
Nature Portfolio
Subjects:
631/337/1427
631/45/468
631/67/68
Aspartic Acid Proteases - metabolism
Biology
Biomedical and Life Sciences
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA Damage
DNA repair
DNA Replication
DNA-Binding Proteins - metabolism
Genomes
Genomic Instability
Histones
Humans
Life Sciences
Nuclear Proteins - metabolism
Protein Processing, Post-Translational
Proteins
Proteolysis
Receptors, Virus - metabolism
Recombination
Replication
Review
Review Article
Transcription
ISSN:2399-3642, 2399-3642
Online Access:Get full text
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Summary:Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. Research in the past several years indicates that cells possess dedicated enzymes, known as DPC proteases, which digest the protein component of a DPC. Interestingly, DPC proteases also play a role in proteolysis beside DPC repair, such as in degrading excess histones during DNA replication or controlling DNA replication checkpoints. Here, we discuss the importance of DPC proteases in DNA replication, genome stability and their direct link to human diseases and cancer therapy. DNA–protein crosslink (DPC) proteases digest the protein component of crosslinks that otherwise can cause genomic instability and disease. Ruggiano and Ramadan discuss recent insights into the roles of DPC proteases in the repair of DPCs and beyond.
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ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-020-01539-3