Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue

Fluorescent antimicrobial peptides are promising structures for in situ , real-time imaging of fungal infection. Here we report a fluorogenic probe to image Aspergillus fumigatus directly in human pulmonary tissue. We have developed a fluorogenic Trp-BODIPY amino acid with a spacer-free C-C linkage...

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Bibliographic Details
Published in:	Nature communications Vol. 7; no. 1; pp. 10940 - 9
Main Authors:	Mendive-Tapia, Lorena, Zhao, Can, Akram, Ahsan R., Preciado, Sara, Albericio, Fernando, Lee, Martin, Serrels, Alan, Kielland, Nicola, Read, Nick D, Lavilla, Rodolfo, Vendrell, Marc
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.03.2016 Nature Publishing Group Nature Portfolio
Subjects:	14 14/19 14/34 14/69 639/638/11/874 639/638/403 639/638/92/611 639/766/930/2735 Amino acids Antifungal Agents - chemistry Antifungal Agents - pharmacology Antiinfectives and antibacterials Antimicrobial peptides Aspergillosis - diagnosis Aspergillosis - microbiology Aspergillus fumigatus - chemistry Aspergillus fumigatus - drug effects Aspergillus fumigatus - physiology Bacterial infections Boron Compounds - chemistry Diagnostic Imaging - instrumentation Diagnostic Imaging - methods Fluorescence Fluorescent Dyes - chemistry Fungal infections Fungi Human performance Human tissues Humanities and Social Sciences Humans Hydrophobicity Imaging Labeling Lung - microbiology Medical research Microenvironments multidisciplinary Organic chemistry Peptides Peptides - chemistry Peptides - pharmacology Permeability Probes Science Science (multidisciplinary) Selectivity United Kingdom > UK Spain
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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