Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

Activation of microglia in the spinal cord following peripheral nerve injury is critical for the development of long-lasting pain hypersensitivity. However, it remains unclear whether distinct microglia subpopulations or states contribute to different stages of pain development and maintenance. Usin...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 843 - 16
Main Authors:	Tansley, Shannon, Uttam, Sonali, Ureña Guzmán, Alba, Yaqubi, Moein, Pacis, Alain, Parisien, Marc, Deamond, Haley, Wong, Calvin, Rabau, Oded, Brown, Nicole, Haglund, Lisbet, Ouellet, Jean, Santaguida, Carlo, Ribeiro-da-Silva, Alfredo, Tahmasebi, Soroush, Prager-Khoutorsky, Masha, Ragoussis, Jiannis, Zhang, Ji, Salter, Michael W., Diatchenko, Luda, Healy, Luke M., Mogil, Jeffrey S., Khoutorsky, Arkady
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.02.2022 Nature Publishing Group Nature Portfolio
Subjects:	14 14/19 38 45 631/378/2596/1953 692/699/375/1692 Animals Apolipoprotein E Apolipoproteins E - genetics Cell Proliferation Chronic pain Chronic Pain - genetics Developmental stages Female Gene Expression Gene sequencing Humanities and Social Sciences Hypersensitivity Inflammation Injuries Male Males Mice Mice, Inbred C57BL Microglia multidisciplinary Pain Peripheral Nerve Injuries Peripheral nerves Peripheral neuropathy Polymorphism, Genetic Ribonucleic acid RNA Science Science (multidisciplinary) Sequence analysis Sequence Analysis, RNA Sex Spinal Cord Spinal cord injuries Subpopulations Transcription
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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