Time-resolved structure-function coupling in brain networks

The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we study structure-function coupling from a dynamic perspective, and show that...

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Veröffentlicht in:Communications biology Jg. 5; H. 1; S. 532 - 10
Hauptverfasser: Liu, Zhen-Qi, Vázquez-Rodríguez, Bertha, Spreng, R. Nathan, Bernhardt, Boris C., Betzel, Richard F., Misic, Bratislav
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 02.06.2022
Nature Publishing Group
Nature Portfolio
Schlagworte:
631/378/116/1925
631/378/116/2393
Biology
Biomedical and Life Sciences
Cortex (frontal)
Cortex (insular)
Cortex (temporal)
Functional anatomy
Functional magnetic resonance imaging
Life Sciences
Methods
Nervous system
Neural networks
Neurosciences
Structure-function relationships
ISSN:2399-3642, 2399-3642
Online-Zugang:Volltext
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Zusammenfassung:The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we study structure-function coupling from a dynamic perspective, and show that it is regionally heterogeneous. We use a temporal unwrapping procedure to identify moment-to-moment co-fluctuations in neural activity, and reconstruct time-resolved structure-function coupling patterns. We find that patterns of dynamic structure-function coupling are region-specific. We observe stable coupling in unimodal and transmodal cortex, and dynamic coupling in intermediate regions, particularly in insular cortex (salience network) and frontal eye fields (dorsal attention network). Finally, we show that the variability of a region’s structure-function coupling is related to the distribution of its connection lengths. Collectively, our findings provide a way to study structure-function relationships from a dynamic perspective. Temporal unwrapping analysis of diffusion weighted MRI connectivity and functional MRI scans reveals that the coupling between structure and function in the human brain is regionally heterogeneous and provides a framework to evaluate these relationships from a dynamic perspective.
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ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-022-03466-x