Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum

The mechanisms governing neutrophil response to Mycobacterium tuberculosis remain poorly understood. In this study we utilise biotagging, a novel genome-wide profiling approach based on cell type-specific in vivo biotinylation in zebrafish to analyse the initial response of neutrophils to Mycobacter...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; pp. 6505 - 14
Main Authors:	Kenyon, Amy, Gavriouchkina, Daria, Zorman, Jernej, Napolitani, Giorgio, Cerundolo, Vincenzo, Sauka-Spengler, Tatjana
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26.07.2017 Nature Publishing Group Nature Portfolio
Subjects:	13 14 14/19 14/63 38 38/22 38/32 38/39 38/77 38/90 38/91 631/250/2504/223/1699 631/337/2019 64/116 Animals Biotinylation Caspase CRISPR Disease Models, Animal Egr-3 protein Gene expression Gene Expression Profiling Genomes Granuloma Humanities and Social Sciences Immunity, Innate Inflammasomes Inflammasomes - metabolism Interleukin 1 Leukocytes (neutrophilic) Macrophages multidisciplinary Mycobacterium Infections, Nontuberculous - pathology Mycobacterium marinum Mycobacterium marinum - immunology Neutrophils Neutrophils - immunology Proteolysis Ribonucleic acid RNA Science Science (multidisciplinary) Sequence Analysis, RNA Transcription Tuberculosis Zebrafish
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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