The good, the bad, and the ugly: hyperprogression in cancer patients following immune checkpoint therapy

Editorial summary Immune checkpoint blockade therapy can elicit robust and durable responses in a variety of cancer types. While many patients do not respond, recent reports highlight a distinct group of patients whose tumors undergo rapid growth, leading to progressive disease and poor outcome. In...

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Vydáno v:Genome medicine Ročník 11; číslo 1; s. 43 - 3
Hlavní autoři: Sabio, Erich, Chan, Timothy A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 24.07.2019
BioMed Central Ltd
BMC
Témata:
Antigen
Antigens
Antineoplastic Agents, Immunological - pharmacology
Antineoplastic Agents, Immunological - therapeutic use
Bioinformatics
Biomarkers, Tumor - antagonists & inhibitors
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer patients
Cancer Research
Comment
Disease Progression
Gene mutation
Genetic aspects
Human Genetics
Humans
Hyperprogression
Immune checkpoint
Immunomodulation - drug effects
Immunomodulation - genetics
Medicine/Public Health
Metabolomics
Molecular Targeted Therapy
Mutation
Neoplasms - drug therapy
Neoplasms - etiology
Neoplasms - pathology
Risk Factors
Systems Biology
T cells
T-Lymphocyte Subsets - drug effects
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
Treatment Outcome
Tumor immune microenvironment and immunotherapy
Tumors
Antigen
Immune checkpoint
Mutation
Hyperprogression
T cells
Cancer
ISSN:1756-994X, 1756-994X
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Shrnutí:Editorial summary Immune checkpoint blockade therapy can elicit robust and durable responses in a variety of cancer types. While many patients do not respond, recent reports highlight a distinct group of patients whose tumors undergo rapid growth, leading to progressive disease and poor outcome. In this perspective, we synthesize and summarize some important issues surrounding hyperprogression, defining characteristics, prognostic implications, and controversies.
Bibliografie:ObjectType-Article-1
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ObjectType-Review-3
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ISSN:1756-994X
1756-994X
DOI:10.1186/s13073-019-0661-7