COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants

As SARS-CoV-2 has been circulating for over a year, dozens of vaccine candidates are under development or in clinical use. The BNT162b2 mRNA COVID-19 vaccine induces spike protein-specific neutralizing antibodies associated with protective immunity. The emergence of the B.1.1.7 and B.1.351 variants...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 3991 - 11
Main Authors:	Jalkanen, Pinja, Kolehmainen, Pekka, Häkkinen, Hanni K., Huttunen, Moona, Tähtinen, Paula A., Lundberg, Rickard, Maljanen, Sari, Reinholm, Arttu, Tauriainen, Sisko, Pakkanen, Sari H., Levonen, Iris, Nousiainen, Arttu, Miller, Taru, Välimaa, Hanna, Ivaska, Lauri, Pasternack, Arja, Naves, Rauno, Ritvos, Olli, Österlund, Pamela, Kuivanen, Suvi, Smura, Teemu, Hepojoki, Jussi, Vapalahti, Olli, Lempainen, Johanna, Kakkola, Laura, Kantele, Anu, Julkunen, Ilkka
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.06.2021 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 631/250/2152/2153/1291 631/250/590/2293 631/326/590/2293 631/326/596/4130 82/1 Adult Aged Aged, 80 and over Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology BNT162 Vaccine Broadly Neutralizing Antibodies - blood Broadly Neutralizing Antibodies - immunology Coronaviruses COVID-19 COVID-19 - blood COVID-19 - epidemiology COVID-19 - immunology COVID-19 - prevention & control COVID-19 vaccines COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Cross Protection - immunology Dosage Female Finland - epidemiology Health care Humanities and Social Sciences Humans Immunization, Secondary - methods Immunization, Secondary - statistics & numerical data Immunogenicity, Vaccine Male Mass Vaccination - methods Mass Vaccination - statistics & numerical data Medical personnel Middle Aged mRNA multidisciplinary Mutation Neutralization Neutralization Tests - statistics & numerical data Proteins Reinfection - immunology Reinfection - prevention & control Reinfection - virology SARS-CoV-2 - genetics SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spike protein Vaccine efficacy Vaccines Young Adult Finland
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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