SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA replication in vertebrate cells. Cells deficient in SPRTN protease exhibit DPC-induced replication stress and genome instability, manifesting as premature ageing and liver cancer. Here, we provide a body of evidenc...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 3142 - 18
Main Authors:	Halder, Swagata, Torrecilla, Ignacio, Burkhalter, Martin D., Popović, Marta, Fielden, John, Vaz, Bruno, Oehler, Judith, Pilger, Domenic, Lessel, Davor, Wiseman, Katherine, Singh, Abhay Narayan, Vendrell, Iolanda, Fischer, Roman, Philipp, Melanie, Ramadan, Kristijan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.07.2019 Nature Publishing Group Nature Portfolio
Subjects:	13 13/106 13/31 13/44 13/51 14 14/1 42 42/70 42/89 631/337/151/2353 631/80/474 64 64/116 82/83 Activation Aging Animals Checkpoint Kinase 1 - metabolism Checkpoint Kinase 1 - physiology CHK1 protein Chromatin Crosslinking Deoxyribonucleic acid DNA DNA biosynthesis DNA Breaks DNA repair DNA Replication DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Fragments Genomes Genomic Instability Humanities and Social Sciences Kinases Liver cancer Metalloproteinase Models, Genetic multidisciplinary Phosphorylation Protease Proteolysis Repair Replication Science Science (multidisciplinary) Signal Transduction Stability Vertebrates Zebrafish - genetics Zebrafish - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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