SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA replication in vertebrate cells. Cells deficient in SPRTN protease exhibit DPC-induced replication stress and genome instability, manifesting as premature ageing and liver cancer. Here, we provide a body of evidenc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature communications Jg. 10; H. 1; S. 3142 - 18
Hauptverfasser:	Halder, Swagata, Torrecilla, Ignacio, Burkhalter, Martin D., Popović, Marta, Fielden, John, Vaz, Bruno, Oehler, Judith, Pilger, Domenic, Lessel, Davor, Wiseman, Katherine, Singh, Abhay Narayan, Vendrell, Iolanda, Fischer, Roman, Philipp, Melanie, Ramadan, Kristijan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 17.07.2019 Nature Publishing Group Nature Portfolio
Schlagworte:	13 13/106 13/31 13/44 13/51 14 14/1 42 42/70 42/89 631/337/151/2353 631/80/474 64 64/116 82/83 Activation Aging Animals Checkpoint Kinase 1 - metabolism Checkpoint Kinase 1 - physiology CHK1 protein Chromatin Crosslinking Deoxyribonucleic acid DNA DNA biosynthesis DNA Breaks DNA repair DNA Replication DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Fragments Genomes Genomic Instability Humanities and Social Sciences Kinases Liver cancer Metalloproteinase Models, Genetic multidisciplinary Phosphorylation Protease Proteolysis Repair Replication Science Science (multidisciplinary) Signal Transduction Stability Vertebrates Zebrafish - genetics Zebrafish - metabolism
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!