Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa

Bacteria and many non-metazoan Eukaryotes respond to stresses and threats using two-component systems (TCSs) comprising sensor kinases (SKs) and response regulators (RRs). Multikinase networks, where multiple SKs work together, detect and integrate different signals to control important lifestyle de...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 2219 - 11
Main Authors:	Francis, Vanessa I., Waters, Elaine M., Finton-James, Sutharsan E., Gori, Andrea, Kadioglu, Aras, Brown, Alan R., Porter, Steven L.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.06.2018 Nature Publishing Group Nature Portfolio
Subjects:	13/95 38/1 38/111 38/88 42/70 45 45/29 45/77 49 631/326/1320 631/326/421 631/45/275 631/553/2711 64 64/60 692/420/254 82/80 82/83 96 Animals Anti-Bacterial Agents - therapeutic use Bacterial Proteins - metabolism Biofilms Communication Cystic fibrosis Data processing Disease Models, Animal Eukaryotes Female Humanities and Social Sciences Humans Infections Kinases Mice Mice, Inbred BALB C Moths multidisciplinary Phosphatase Phosphorylation Phosphorylation - physiology Phosphotransferases - metabolism Protein Domains - physiology Protein Interaction Maps - physiology Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - pathogenicity Pseudomonas aeruginosa - physiology Pseudomonas Infections - drug therapy Pseudomonas Infections - microbiology Pseudomonas Infections - mortality Regulators Science Science (multidisciplinary) Sensors Signal processing Signal Transduction - physiology Sporulation Switching theory Transmitters Virulence Virulence - physiology Virulence Factors - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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