Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa

Bacteria and many non-metazoan Eukaryotes respond to stresses and threats using two-component systems (TCSs) comprising sensor kinases (SKs) and response regulators (RRs). Multikinase networks, where multiple SKs work together, detect and integrate different signals to control important lifestyle de...

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Veröffentlicht in:Nature communications Jg. 9; H. 1; S. 2219 - 11
Hauptverfasser: Francis, Vanessa I., Waters, Elaine M., Finton-James, Sutharsan E., Gori, Andrea, Kadioglu, Aras, Brown, Alan R., Porter, Steven L.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 07.06.2018
Nature Publishing Group
Nature Portfolio
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Animals
Anti-Bacterial Agents - therapeutic use
Bacterial Proteins - metabolism
Biofilms
Communication
Cystic fibrosis
Data processing
Disease Models, Animal
Eukaryotes
Female
Humanities and Social Sciences
Humans
Infections
Kinases
Mice
Mice, Inbred BALB C
Moths
multidisciplinary
Phosphatase
Phosphorylation
Phosphorylation - physiology
Phosphotransferases - metabolism
Protein Domains - physiology
Protein Interaction Maps - physiology
Proteins
Pseudomonas aeruginosa
Pseudomonas aeruginosa - pathogenicity
Pseudomonas aeruginosa - physiology
Pseudomonas Infections - drug therapy
Pseudomonas Infections - microbiology
Pseudomonas Infections - mortality
Regulators
Science
Science (multidisciplinary)
Sensors
Signal processing
Signal Transduction - physiology
Sporulation
Switching theory
Transmitters
Virulence
Virulence - physiology
Virulence Factors - metabolism
ISSN:2041-1723, 2041-1723
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Bacteria and many non-metazoan Eukaryotes respond to stresses and threats using two-component systems (TCSs) comprising sensor kinases (SKs) and response regulators (RRs). Multikinase networks, where multiple SKs work together, detect and integrate different signals to control important lifestyle decisions such as sporulation and virulence. Here, we study interactions between two SKs from Pseudomonas aeruginosa , GacS and RetS, which control the switch between acute and chronic virulence. We demonstrate three mechanisms by which RetS attenuates GacS signalling: RetS takes phosphoryl groups from GacS-P; RetS has transmitter phosphatase activity against the receiver domain of GacS-P; and RetS inhibits GacS autophosphorylation. These mechanisms play important roles in vivo and during infection, and exemplify an unprecedented degree of signal processing by SKs that may be exploited in other multikinase networks. Bacteria respond to stresses using two-component systems consisting of sensor kinases (SKs) and response regulators. Here, Francis et al . reveal three specific interaction mechanisms between a pair of SKs that are important for regulation of virulence in the pathogen Pseudomonas aeruginosa .
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-018-04640-8