CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote and restrain disease progression. Here, we interrogate how cancer cells harboring distinct alterations in p53 manipulate CAFs. We reveal the existence of a p53-driven hierarch...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 3637 - 22
Main Authors:	Vennin, Claire, Mélénec, Pauline, Rouet, Romain, Nobis, Max, Cazet, Aurélie S., Murphy, Kendelle J., Herrmann, David, Reed, Daniel A., Lucas, Morghan C., Warren, Sean C., Elgundi, Zehra, Pinese, Mark, Kalna, Gabriella, Roden, Daniel, Samuel, Monisha, Zaratzian, Anaiis, Grey, Shane T., Da Silva, Andrew, Leung, Wilfred, Mathivanan, Suresh, Wang, Yingxiao, Braithwaite, Anthony W., Christ, Daniel, Benda, Ales, Parkin, Ashleigh, Phillips, Phoebe A., Whitelock, John M., Gill, Anthony J., Sansom, Owen J., Croucher, David R., Parker, Benjamin L., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., Timpson, Paul
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.08.2019 Nature Publishing Group Nature Portfolio
Subjects:	13 13/106 14/3 14/33 14/5 14/69 38/61 59/5 631/67 631/67/327 631/80 64/60 82/58 Animals Cancer Cancer-Associated Fibroblasts - pathology Cell Line, Tumor Cell Movement Cell Proliferation Chemotherapy Drug Resistance, Neoplasm - genetics Fibroblasts Gene Expression Regulation, Neoplastic - genetics Heparan Sulfate Proteoglycans - metabolism Humanities and Social Sciences Metastases Metastasis Mice Mice, Inbred BALB C multidisciplinary Neoplasm Invasiveness - pathology p53 Protein Pancreas - pathology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Perlecan Science Science (multidisciplinary) Signal Transduction - physiology Stroma Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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