Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in o...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 302 - 14
Main Authors:	Eskenazi, Anaïs, Lood, Cédric, Wubbolts, Julia, Hites, Maya, Balarjishvili, Nana, Leshkasheli, Lika, Askilashvili, Lia, Kvachadze, Leila, van Noort, Vera, Wagemans, Jeroen, Jayankura, Marc, Chanishvili, Nina, de Boer, Mark, Nibbering, Peter, Kutateladze, Mzia, Lavigne, Rob, Merabishvili, Maya, Pirnay, Jean-Paul
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.01.2022 Nature Publishing Group Nature Portfolio
Subjects:	631/326/107 631/326/1321 692/699/255/1318 692/700/565 Adult Anti-Bacterial Agents - therapeutic use Antibiotics Azabicyclo Compounds - pharmacology Azabicyclo Compounds - therapeutic use Bacteriophages - genetics Bacteriophages - ultrastructure Biofilms Biofilms - drug effects Ceftazidime Ceftazidime - pharmacology Ceftazidime - therapeutic use Colistin CpG Islands - genetics Drug Combinations Drug Resistance, Microbial - drug effects Drug Resistance, Microbial - genetics Drug Resistance, Multiple, Bacterial Fractures, Bone - complications Fractures, Bone - diagnostic imaging Fractures, Bone - microbiology Genome, Viral Humanities and Social Sciences Humans Infections Klebsiella Klebsiella Infections - complications Klebsiella Infections - diagnostic imaging Klebsiella Infections - microbiology Klebsiella Infections - therapy Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Klebsiella pneumoniae - physiology Meropenem Microbial Sensitivity Tests multidisciplinary Patients Phage Therapy Phages Polymorphism, Single Nucleotide - genetics Proteomics Replicon - genetics Science Science (multidisciplinary) Therapy
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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