Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in o...

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Vydáno v:	Nature communications Ročník 13; číslo 1; s. 302 - 14
Hlavní autoři:	Eskenazi, Anaïs, Lood, Cédric, Wubbolts, Julia, Hites, Maya, Balarjishvili, Nana, Leshkasheli, Lika, Askilashvili, Lia, Kvachadze, Leila, van Noort, Vera, Wagemans, Jeroen, Jayankura, Marc, Chanishvili, Nina, de Boer, Mark, Nibbering, Peter, Kutateladze, Mzia, Lavigne, Rob, Merabishvili, Maya, Pirnay, Jean-Paul
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 18.01.2022 Nature Publishing Group Nature Portfolio
Témata:	631/326/107 631/326/1321 692/699/255/1318 692/700/565 Adult Anti-Bacterial Agents - therapeutic use Antibiotics Azabicyclo Compounds - pharmacology Azabicyclo Compounds - therapeutic use Bacteriophages - genetics Bacteriophages - ultrastructure Biofilms Biofilms - drug effects Ceftazidime Ceftazidime - pharmacology Ceftazidime - therapeutic use Colistin CpG Islands - genetics Drug Combinations Drug Resistance, Microbial - drug effects Drug Resistance, Microbial - genetics Drug Resistance, Multiple, Bacterial Fractures, Bone - complications Fractures, Bone - diagnostic imaging Fractures, Bone - microbiology Genome, Viral Humanities and Social Sciences Humans Infections Klebsiella Klebsiella Infections - complications Klebsiella Infections - diagnostic imaging Klebsiella Infections - microbiology Klebsiella Infections - therapy Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Klebsiella pneumoniae - physiology Meropenem Microbial Sensitivity Tests multidisciplinary Patients Phage Therapy Phages Polymorphism, Single Nucleotide - genetics Proteomics Replicon - genetics Science Science (multidisciplinary) Therapy
ISSN:	2041-1723, 2041-1723
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Shrnutí:	A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient’s wounds and overall condition. In support, the bacteriophage and antibiotic combination is highly effective against the patient’s K. pneumoniae strain in vitro, in 7-day mature biofilms and in suspensions. In this case study of a patient with fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term antibiotic therapy, the authors use a combination therapy of pre-adapted bacteriophage and antibiotics resulting in clinical, microbiological and radiological improvement.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Case Study-2 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-021-27656-z