Immunological and inflammatory profiles in mild and severe cases of COVID-19

COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19....

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Vydané v:	Nature communications Ročník 11; číslo 1; s. 3410 - 10
Hlavní autori:	Song, Jin-Wen, Zhang, Chao, Fan, Xing, Meng, Fan-Ping, Xu, Zhe, Xia, Peng, Cao, Wen-Jing, Yang, Tao, Dai, Xiao-Peng, Wang, Si-Yu, Xu, Ruo-Nan, Jiang, Tian-Jun, Li, Wen-Gang, Zhang, Da-Wei, Zhao, Peng, Shi, Ming, Agrati, Chiara, Ippolito, Giuseppe, Maeurer, Markus, Zumla, Alimuddin, Wang, Fu-Sheng, Zhang, Ji-Yuan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 08.07.2020 Nature Publishing Group Nature Portfolio
Predmet:	13/1 13/21 13/31 13/51 631/250/254 631/250/255/2514 631/250/256/2516 Adult Aged Aged, 80 and over Betacoronavirus - immunology Betacoronavirus - pathogenicity Biomarkers - metabolism CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell activation Chemotaxis, Leukocyte China - epidemiology Coronavirus Infections - blood Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 Cytokines - blood Cytotoxicity Epidemiology Female Humanities and Social Sciences Humans Immune system Immunology Inflammation Killer Cells, Natural - immunology Killer Cells, Natural - pathology Leukocyte Count Lung - immunology Lung - virology Lymphocyte Activation Lymphocytes Lymphocytes T Lymphopenia Macrophages Male Middle Aged multidisciplinary Pandemics Pathogenesis Patients Pneumonia, Viral - blood Pneumonia, Viral - immunology Pneumonia, Viral - pathology Pneumonia, Viral - virology Ribonucleic acid RNA SARS-CoV-2 Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Therapeutic applications Toxicity Viral diseases China
ISSN:	2041-1723, 2041-1723
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Shrnutí:	COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients. Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-020-17240-2